MA Nilfroush Zadeh; N Anasri; R Derakhshan
Volume 8, Issue 6 , 2006, , Pages 457-461
Abstract
Background and aim: Pentavalent antimony compounds are the first line treatment for cutaneous leishmaniasis. Clinical resistance to pentavalent antimony in the form of meglumine antimoniate (Glucantime) has been recognized as a problem in leishmaniasis. Herein, clinical response to Glucantime were studied ...
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Background and aim: Pentavalent antimony compounds are the first line treatment for cutaneous leishmaniasis. Clinical resistance to pentavalent antimony in the form of meglumine antimoniate (Glucantime) has been recognized as a problem in leishmaniasis. Herein, clinical response to Glucantime were studied in patients suffered from cutaneous leishmaniasis.Materials and Methods: In a cross-sectional study 370 patients with cutaneous leishmaniasis were treated with systemic Glucantime, 50 mg/kg/day, for 2 to 3 weeks. They were visited weekly for 3 weeks and also followed up for 3 months after treatment was completed. The clinical and parasitological response to this treatment was evaluated, and classified into partial and complete response and failure to treatment. Results: Two hundred forty-seven men and 123 women were followed up. The mean age was 36.7±16 years. There were 64.1% partial response after 2 weeks and 73% partial response at the third week of treatment. 11.6% of lesions were not cured after 3 weeks of treatment and 8.1% were not still cured 12 weeks thereafter.Conclusion: Clinical resistance to Glucantime is an important problem. The mechanisms of resistance and using drug combinations are needed to be considered.
G Sadeghian; MA Nilfroush Zadeh; M Amini
Volume 8, Issue 6 , 2006, , Pages 466-470
Abstract
Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of ...
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Background and aim: Acanthosis nigricans (AN) is characterized by hyperpigmented velvety plaques of body folds and neck. Insulin can have a role in the pathogenesis of this disease and hyperinsulinemia as a consequence of insulin resistance may stimulate the formation of the characteristic plaques of AN. In this study insulin resistance was compared in obese women with and without AN.Materials and Methods: Glucose tolerance test (GTT) and fasting blood insulin were measured in two groups of obese women (BMI>30 kg/m2) with AN (32 cases) and without AN (34 cases) and insulin resistance was determined using HOMA formula.Results: The mean fasting blood insulin in two groups with and without AN were 15.5±8.5 and 12.2±4.1 IU/mL; respectively (P<0.05). The mean of insulin resistance in two groups with and without AN were 3.5±1.9 and 2.6±0.9; respectively (P<0.05). The results of GTT showed that the mean fasting blood sugar was 89.5±12 mg/dl and following using glucose were 144±7 mg/dl after 30 minutes, 132±45 mg/dl after 60 minutes, 107±30 mg/dl after 120 minutes in persons with AN and in the other group were 87±8, 130±3, 122±26 and 100±26 mg/dl; respectively. The difference between two groups was only significant after 60 minutes.Conclusion: Acanthosis nigricans maybe a marker of insulin resistance in obese women.